Ajani, Olayinka O. and Familoni, Oluwole B. and Echeme, Johnbull O. and Wu, Feipeng and Sujiang, Zheng (2013) Synthesis and Antibacterial Activity of N,N-Diethylamide Bearing Benzenesulfonamide Derivatives. American Chemical Science Journal, 3 (1). pp. 34-49. ISSN 22490205
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Abstract
Sulfonamides are known to represent a class of medicinally important compounds which are extensively used as antibacterial agents. Hence, a series of new N,N-diethyl amide bearing sulfonamides (2a-k) were synthesized via amidation of easily prepared benzenesulfonamide precursors (1a-k). The chemical structures of all synthesized compounds were substantiated using spectroscopic means such as IR, Mass spectra and 1H-NMR as well as analytical data. The antimicrobial activity of these compounds along with streptomycin, was investigated on Escherichia coli and Staphylococcus aureus. The results showed that this skeletal framework exhibited marked potency as antibacterial agents. The most active antibacterial agent against both targeted organisms was N,N-diethyl-1-(phenylsulfonyl) piperidine-2-carboxamide (2b).
Item Type: | Article |
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Subjects: | Open Library Press > Chemical Science |
Depositing User: | Unnamed user with email support@openlibrarypress.com |
Date Deposited: | 21 Jun 2023 11:59 |
Last Modified: | 21 Jun 2023 11:59 |
URI: | https://openlibrarypress.com/id/eprint/1701 |