Coronary Heart Disease Secondary to Familial Hypercholesterolemia: A Fast Killer

Familial hypercholesterolemia is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been shown to be associated with increased coronary heart disease and premature death. We report two cases of homozygote familial hypercholesterolemia (IIa) in brothers, presenting coronary artery disease at an early age, with a very disturbed lipid profile, rapidly progressive and diffuse coronary lesions, with the occurrence of early death in both brothers before the age of 30.